2022 Fiscal Year Final Research Report
Analysis of MLH1-high methylation in ctDNA-liquid biopsy from uterine endometrial cancer
Project/Area Number |
20K18197
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 56040:Obstetrics and gynecology-related
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Research Institution | Wakayama Medical University |
Principal Investigator |
Deguchi Yoko 和歌山県立医科大学, 医学部, 準客員研究員 (00869612)
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | リキッドバイオプシー / 子宮体癌 |
Outline of Final Research Achievements |
Here, we show the usefulness of liquid biopsy in uterine endometrial cancer. In this study, we examined the MLH1-high methylation in ctDNA-liquid biopsy from uterine endometrial cancer patients. We established high accuracy degree of the MLH1-high methylation in ctDNA-liquid biopsy. These findings suggest that the characterization of the genetic profiles of independent tumors using liquid biopsy may lead to the development of novel personalized treatment strategies in uterine endometrial cancer.
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Free Research Field |
産婦人科
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Academic Significance and Societal Importance of the Research Achievements |
これまで解明されていなかった、子宮体癌患者血液ctDNAを用いたMLH1-高メチル化解析法について検討し、有用性を示せた。個別化医療に対しては今後はctDNA-Liquid Biopsyは必須項目となってくることが考えられ、研究成果の学術的意義や社会的意義は高いと考えられる。
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