Attempts to develop new ovarian stimulation methods for aging infertile patients.

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K18198
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: Tokyo Medical and Dental University (2022-2023); International University of Health and Welfare (2020-2021)
• Principal Investigator: Okamoto Naoki 東京医科歯科大学, 生体材料工学研究所, 非常勤講師 (80714360)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 新規卵巣刺激法 / FSH抵抗性 / 不妊治療

Outline of Final Research Achievements

Previous studies have confirmed the data that ovarian stimulation of aging mice resistant to ovarian stimulation with FSH was replaced by CNP, resulting in an increase in the number of ovulations. This confirms the possibility that CNP ovarian stimulation may be effective for aged mice in which ovarian stimulation with FSH is unsuccessful. In addition, we have clarified one aspect of the mechanism by which CNP are involved in follicle growth. This study has provided useful data for establishing a new ovarian stimulation method using CNP.

Free Research Field

生殖内分泌

Academic Significance and Societal Importance of the Research Achievements

本研究で卵巣におけるCNPの働きの一端を明らかにできたことは、学術的に意義のあることと考える。また、CNPを用いた新規卵巣刺激法の開発に向けて、有用なデータを得ることができた。この新規卵巣刺激法が確立できれば、FSHの刺激に対して抵抗性を示す不妊患者に対し有効な治療手段となることが期待でき、社会的意義のあるものと考える。