Analysis of the role of exosomes as maternal-fetal molecular communication tools

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K18199
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: Saitama Medical University
• Principal Investigator: Tochigi Hidden 埼玉医科大学, 医学部, 非常勤講師 (90623695)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 着床 / マイクロRNA / 脱落膜化 / 不妊症

Outline of Final Research Achievements

miRNA regulate the expression and localization of FOXO1, and their downstream SCARA5 expression is suggested to play an important role in the decidualization process.

Free Research Field

生殖医学

Academic Significance and Societal Importance of the Research Achievements

本研究により、子宮内膜の脱落膜化過程で発現量が変化するmiRNAのうち、これまでに明らかになっていなかったmiRNAの機能が明らかとなった。このことは、不妊症や妊娠高血圧症等の産婦人科疾患の新規の治療法や診断の確立に役立てることが考えられる。