Molecular classification and personalised treatment for ovarian clear cell carcinoma using the OCCC gene panel

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K18202
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: Jikei University School of Medicine
• Principal Investigator: Kawabata Ayako 東京慈恵会医科大学, 医学部, 助教 (90594573)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 卵巣明細胞癌 / がん遺伝子パネル

Outline of Final Research Achievements

This study established The Jikei OCCC Oncopanel, specific to ovarian clear cell carcinoma (OCCC), and comprehensively analysed OCCC-related genetic abnormalities in the Japanese population. In addition, The Jikei OCCC Oncopanel is a database of OCCC gene expression profiles by RNA sequencing, immunohistochemistry, and morphological features, and was integrated into the Jikei OCCC Oncopanel to establish OCCC molecular subtypes and individualised treatment.DNA targeted sequencing of 100 genes was performed on 80 OCCC cases.
The genomic profiles, immunohistochemical staining of proteins and morphological features of the 80 cases were integrated and examined, but a molecular subtype could not be proposed.

Free Research Field

Gynecology

Academic Significance and Societal Importance of the Research Achievements

がん遺伝子パネル検査が保険収載され，がんゲノム医療が急速に普及している．卵巣癌を対象としたパネルも開発されているが，OCCCに特化したがん遺伝子パネル検査はない．
本研究はOCCCに特化したがん遺伝子パネル『The Jikei CCC Oncopanel』を創出し，日本人のOCCC関連遺伝子異常を網羅的に解析しデータベースを構築する．また，RNAシーケンスによるOCCC遺伝子発現プロファイル，タンパクの免疫組織化学染色，形態学的特徴のデータベースと統合し，OCCCのMolecular subtypeの提唱および個別化治療の確立を目指す．