Development of new therapeutic strategies targeting ANGPTL2 in ovarian cancer

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K18223
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: Kumamoto University
• Principal Investigator: TAKESHITA YUKO 熊本大学, 大学院生命科学研究部(医), 特定研究員 (40838645)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 卵巣癌 / 腹膜播種 / ANGPTL2 / 細胞接着

Outline of Final Research Achievements

We focused on angiopoietin like protein 2 (ANGPTL2), an angiogenic factor involved in carcinogenesis, tumor invasion, and metastasis in carcinomas, to elucidate the function of this molecule in peritoneal dissemination of ovarian cancer.
In this study, we generated an in vivo mouse model of peritoneal dissemination of ovarian cancer. The results of a series of analyses showed that tumor-expressed ANGPTL2 suppresses peritoneal metastasis in vivo.
In conclusion, regulation of ANGPTL2 expression in ovarian cancer has the potential to be applied to the development of methods to control peritoneal dissemination of ovarian cancer.

Free Research Field

卵巣癌

Academic Significance and Societal Importance of the Research Achievements

卵巣癌におけるANGPTL2の発現を抑制することは、卵巣癌の腹膜播種病巣の形成の制御法の開発に応用できる可能性を有している。しかしながら、今後、ヒト卵巣癌組織あるいは腹水中でのANGPTL2の発現検討など、より詳細で網羅的な解析を行うことで、卵巣癌におけるANGPTL2の発現意義のさらなる解明が必要である。