Elucidation of the pathogenesis of refractory ECRS focusing on glycosylation by glycosyltransferases

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K18252
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56050:Otorhinolaryngology-related
• Research Institution: Osaka University
• Principal Investigator: Nakatani Ayaka 大阪大学, 医学部附属病院, 医員 (80846395)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 好酸球性副鼻腔炎 / ECRS / 好酸球

Outline of Final Research Achievements

We evaluated the expression of glycosyltransferase-related genes in sinonasal tissue specimens (inferior nasal concha, middle nasal concha, and polyps) and identified glycans that are highly expressed in the ECRS.
In the middle nasal concha of ECRS, the expression of glycosyltransferaserelated gene B3GNT7 was found to be enhanced, and Siglec8 was highly expressed in the ECRS nasal polyps tissue, and keratan sulfate was also expressed in the same region. It is suggested that glycosyltransferases and induced keratan sulfate may regulate eosinophilic inflammation in ECRS.

Free Research Field

耳鼻咽喉科学

Academic Significance and Societal Importance of the Research Achievements

ECRSにおいて糖転移酵素が果たす役割を検討した研究は未だ少なく、ECRSの研究・抗体薬はサイトカインをターゲットにするものが大半であり、上皮細胞における糖鎖修飾を標的とした治療薬の開発は少ない。
本研究では、ECRSで高発現している糖鎖について明らかにし、アレルギー炎症における糖鎖修飾について解明するという点で基礎医学的観点からも重要であると考えられ、難治性副鼻腔炎における新たな治療ターゲットとなる可能性が見いだされた。