Research for the Mechanism of Refractory Eosinophilic Sinusitis through Osteoblasts Mediated by BMP8B

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K18281
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56050:Otorhinolaryngology-related
• Research Institution: Osaka University
• Principal Investigator: Obata Sho 大阪大学, 大学院医学系研究科, 特任助教(常勤) (50846409)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: BMP8B / 好酸球 / EEtosis

Outline of Final Research Achievements

We investigated the mechanism of refractory eosinophilic sinusitis mediated by osteoblasts through BMP8B. In the tissue of eosinophilic sinusitis, we evaluated the expression of BMP8B in various cells using fluorescence immunostaining. It was confirmed that eosinophils undergoing cell death, known as EEtosis, prominently release BMP8B. Additionally, BMP8B was found to be distributed in epithelial cells and glandular tissues, with epithelial cells identified as target cells. We examined the response of epithelial cells to BMP8B and plan to report our findings in a future publication.

Free Research Field

アレルギー

Academic Significance and Societal Importance of the Research Achievements

本研究は、BMP8Bが好酸球性副鼻腔炎の病態形成において果たす役割を解明しました。EEtosisにより好酸球がBMP8Bを放出し、上皮細胞がそのターゲットであることを明らかにしました。学術的には、BMP8BとEEtosisの関連性、特定の細胞相互作用の理解が新たな治療戦略の開発に寄与します。社会的には、効果的な治療法の開発により患者の生活の質向上や医療資源の効率的利用が期待されます。