視神経乳頭・周辺組織による正常近視眼と緑内障近視眼の鑑別

2023 Fiscal Year Annual Research Report

• Project/Area Number: 20K18368
• Research Institution: The University of Tokyo
• Principal Investigator: 西岡 瞳 (齋藤瞳) 東京大学, 医学部附属病院, 講師 (40870069)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 近視 / 光干渉断層撮影 / OCT / myopia / optic nerve head / glaucoma

Outline of Annual Research Achievements

全施設よりデータ取得は完了し、取得した網膜断層像よりlandmark構造となる色素上皮断端、Bruch膜開口部(Bruch's membrane opening: BMO)、前部強膜開口部
（anterior scleral canal opening: ASCO）の位置を手動で同定し、正常眼・緑内障眼ともに構造の解析を独自に開発したソフトにより行った。篩状板関連の組織の同定、形状計測に関しては市販のAIソフトを用いて、解析を行った。得られたデータより眼軸延長とともに変化する視神経乳頭深部組織形状、篩状板前組織剥離と関連する因子、正常眼における乳頭周囲神経線維層およびリム構造の関連因子を検討した。
以下の研究成果を論文として３本発表している。
1) Saito H, et al. Deep Optic Nerve Head Structures Associated With Increasing　Axial Length in Healthy Myopic Eyes of　Moderate Axial Length. Am J Ophthalmol.　May;249:156-166.
2) Saito H, et al. Association of Bergmeister Papilla and Deep Optic Nerve Head Structures With Prelaminar Schisis of Normal and Glaucomatous Eyes. Am J　Ophthalmol. 2024 Jan;257:91-102.
3) Kambayashi M, Saito H, et al. Effects of Deep Optic Nerve Head Structures on Bruch's Membrane Opening- Minimum Rim Width and Peripapillary Retinal Nerve Fiber Layer. Am J Ophthalmol. 2024 Feb 23;263:99-108.

Research Products

• [Int'l Joint Research] University of California San Diego(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: University of California San Diego
• [Int'l Joint Research] Seoul National University(韓国)
  • Country Name: KOREA (REP. OF KOREA)
  • Counterpart Institution: Seoul National University
• [Int'l Joint Research] University of Hong Kong(その他の国・地域)
  • Country Name: その他の国・地域
  • Counterpart Institution: University of Hong Kong
• [Journal Article] Effects of Deep Optic Nerve Head Structures on Bruch's Membrane Opening- Minimum Rim Width and Peripapillary Retinal Nerve Fiber Layer (2024)
  • Author(s): Kambayashi Mitsuki、Saito Hitomi、Araie Makoto、Enomoto Nobuko、Murata Hiroshi、Kikawa Tsutomu、Sugiyama Kazuhisa、Higashide Tomomi、Miki Atsuya、Iwase Aiko、Tomita Goji、Nakazawa Toru、Aihara Makoto、Ohno-Matsui Kyoko、Kim Tae-Woo、Leung Christopher Kai Shun、Zangwill Linda M.、Weinreb Robert N.
  • Journal Title: American Journal of Ophthalmology Volume: 263 Pages: 99～108
  • DOI: 10.1016/j.ajo.2024.02.017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association of Bergmeister Papilla and Deep Optic Nerve Head Structures With Prelaminar Schisis of Normal and Glaucomatous Eyes (2024)
  • Author(s): Saito Hitomi、Ueta Takashi、Araie Makoto、Enomoto Nobuko、Kambayashi Mitsuki、Murata Hiroshi、Kikawa Tsutomu、Sugiyama Kazuhisa、Higashide Tomomi、Miki Atsuya、Iwase Aiko、Tomita Goji、Nakazawa Toru、Aihara Makoto、Ohno-Matsui Kyoko、Kim Tae-Woo、Leung Christopher Kai Shun、Zangwill Linda M.、Weinreb Robert N.
  • Journal Title: American Journal of Ophthalmology Volume: 257 Pages: 91～102
  • DOI: 10.1016/j.ajo.2023.09.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Deep Optic Nerve Head Structures Associated With Increasing Axial Length in Healthy Myopic Eyes of Moderate Axial Length (2023)
  • Author(s): Saito Hitomi、Kambayashi Mitsuki、Araie Makoto、Murata Hiroshi、Enomoto Nobuko、Kikawa Tsutomu、Sugiyama Kazuhisa、Higashide Tomomi、Miki Atsuya、Iwase Aiko、Tomita Goji、Nakazawa Toru、Aihara Makoto、Ohno-Matsui Kyoko、Kim Tae-Woo、Leung Christopher Kai Shun、Zangwill Linda M.、Weinreb Robert N.
  • Journal Title: American Journal of Ophthalmology Volume: 249 Pages: 156～166
  • DOI: 10.1016/j.ajo.2023.01.003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Exploring deep ONH structure changes that accompany myopia and glaucoma (2023)
  • Author(s): Hitomi Saito
  • Organizer: World Glaucoma Congress
  • Int'l Joint Research / Invited