2021 Fiscal Year Final Research Report
Melanogenesis mechanism of retinal pigment epithelium for age-related macular degeneration
| Project/Area Number |
20K18402
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56060:Ophthalmology-related
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2022-03-31
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| Keywords | 網膜色素上皮細胞 / 加齢黄斑変性 / メラニン |
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| Outline of Final Research Achievements |
Age-related macular degeneration (AMD) is a leading cause of blindness in developed countries. The progressive degeneration of the retinal pigment epithelium (RPE) by oxidative stress is a leading factor in its pathogenesis. In this study, we identified a substance that promotes melanin production in RPE based on the fact that melanin in RPE has an antioxidant capacity and decreases following age. The mTOR inhibitor reagent induced the 96% and 93% reduction of transmittance in RPE at two weeks and four weeks, respectively. These results suggested that mTOR inhibitor reagent may be new preventatives against AMD through the promotion of RPE melanin production.
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| Free Research Field |
網膜硝子体分野
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| Academic Significance and Societal Importance of the Research Achievements |
AMDは酸化ストレスによるRPEの機能低下を原因とし、今回mTOR阻害薬が抗酸化能を有するRPEのメラニン生成を促進させることが確認できた。このことから、今後、mTOR阻害薬がAMDに対する新規の予防薬となる可能性が示唆された。
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