Algorithm development for quantitative calculation of lymphatic dynamics using photoacoustic imaging

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K18418
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56070:Plastic and reconstructive surgery-related
• Research Institution: Keio University
• Principal Investigator: Urano Moemi 慶應義塾大学, 医学部(信濃町), 研究員 (70867986)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 光音響 / 光超音波イメージング / リンパ管

Outline of Final Research Achievements

Using a real-time visualization technique of lymphatic flow by photoacoustic imaging, we quantitatively captured the representative movement of lymphatic flow in healthy subjects, verified the accuracy of the measurement, and conducted a basic study toward establishing a quantification algorithm applicable to human subjects.

Free Research Field

光超音波イメージング

Academic Significance and Societal Importance of the Research Achievements

リンパ浮腫の診断、手術計画、治療前後の評価においてリンパ管の機能を定量的に評価することが求められている。本研究を通じて光音響イメージングを用いて生体内のリンパ流の定量的な把握・評価が可能となれば侵襲性が低くさらに精緻な診断ができる可能性が示された。