2021 Fiscal Year Final Research Report
Breakthrough in Oncoplastic Skin Surgery
| Project/Area Number |
20K18431
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56070:Plastic and reconstructive surgery-related
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2022-03-31
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| Keywords | 局所陰圧閉鎖療法 / 悪性腫瘍 / 悪性黒色腫 / メカノバイオロジー |
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| Outline of Final Research Achievements |
Negative pressure wound therapy (NPWT) promotes wound healing by creating a closed wound environment, facilitating wound contraction, removing excessive exudate, reducing edema, physically stimulating cells and tissues, increasing wound bed blood flow, and reducing waste products at a wound site. However, the use of NPWT on residual malignant wounds is contraindicated due to risks of tumorigenesis and cancer spread. This study was designed to clarify the effects of NPWT on malignancy in rodents.
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| Free Research Field |
形成外科
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| Academic Significance and Societal Importance of the Research Achievements |
これまで、悪性腫瘍の残存する創傷に対するNPWTの適用は禁忌とされてきた。しかしながら、NPWTが悪性腫瘍の増殖や上皮間葉転換をもたらすという基礎的なエビデンスは示されていない。NPWTが悪性腫瘍の増悪をきたさないのであれば、術後早期からNPWTを適用することが可能となり、植皮術の適応拡大・整容性向上につながる。NPWTの悪性腫瘍に対する影響を検証した本研究は、今後のNPWTの適応拡大やより適切な使用法の確立に寄与する意義のある研究である。
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