2021 Fiscal Year Final Research Report
the role of HMGB1 in autophagy of malignant melanoma
| Project/Area Number |
20K18438
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56070:Plastic and reconstructive surgery-related
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| Research Institution | Ehime University |
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Principal Investigator |
matsumoto mayu 愛媛大学, 医学部附属病院, 助教(病院教員) (20844765)
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| Project Period (FY) |
2020-04-01 – 2022-03-31
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| Keywords | 悪性黒色腫 / Autophagy / HMGB1 |
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| Outline of Final Research Achievements |
The purpose of this study is to observe the dynamics of HMGB1 related to Autophagy, which is one of the factors that inhibit Apoptosis, and to contribute to the development of antineoplastic drugs.
First, we observed Autophagy in normal human keratinocytes.Next, HMGB1 A-Box, an antagonist of HMGB1, was administered to normal human keratinocytes and cell lines isolated from human malignant melanoma, and changes in autophagy were observed. No clear inhibitory effect of Autophagy was observed compared to before administration of HMGB1 A-Box1.
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| Free Research Field |
皮膚悪性腫瘍
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| Academic Significance and Societal Importance of the Research Achievements |
抗腫瘍薬はがん細胞のapoptosisを促し効果を得るが、腫瘍細胞のAutophagyにより耐性を持つようになる。このAutophagyに関連するタンパクの一つとしてHMGB1があり、この競合作用を持つHMBG1 A-Boxを用いて腫瘍細胞のAutophagyが抑制されるか研究を行った。
結果として、明らかな抑制効果を確認できなかったが、悪性腫瘍に対する治療の開発を目的とした研究であり、社会的に意義のあるものであったと考える。
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