Development of new photocurable haemostatic agents and their application to vascular anastomoses.

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K18452
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56070:Plastic and reconstructive surgery-related
• Research Institution: National Defense Medical College
• Principal Investigator: Tsuchiya Masato 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 病院 形成外科, 助教 (20866735)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 光硬化性ゲル / 止血剤 / 血管吻合

Outline of Final Research Achievements

This research is aimed at realizing effective vascular anastomosis using light-curing gels.The first step was to develop an appropriate light-curing gel for use in the vascular anastomosis, the second step was to use the gel in an animal model of vascular anastomosis, and the third step was to add physiological substances such as growth factors to the gel to promote stability of the vascular anastomosis site.
In the first stage, the time from light irradiation to hardening and the viscosity of the hardened gel could be changed freely by changing the ratio of the constituent substances of the gel.In the second step, hemostasis of micro bleeding in arterial anastomosis was possible, whereas in the venous anastomosis, many occlusions at the anastomosis site were observed. In the third step, the addition of growth factors did not produce significant results.

Free Research Field

微小血管吻合

Academic Significance and Societal Importance of the Research Achievements

光硬化性ゲルを出血のコントロールに用いる研究は既に多く報告されているが,微小血管吻合における有用性の報告は今までなかった。本研究の結果は今後の安全で効率のよい微小血管吻合術の発展に寄与すると考えられる。