Elucidation of blood vessel-mediated bone remodeling regulation mechanism by vascular adhesive osteoclasts

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K18466
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57010:Oral biological science-related
• Research Institution: Matsumoto Dental University (2021); Tokyo Dental College (2020)
• Principal Investigator: Nishida Daisuke 松本歯科大学, 歯学部, 助教 (00843608)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 破骨細胞 / 血管

Outline of Final Research Achievements

Bone maintains its strength by constantly replacing it with new tissue through a remodeling mechanism. It has been reported that the increased vasculature via bone-breaking cells contributes to bone remodeling by inducing bone formation. This event suggests that vascular adhesive osteopathic cells act on vascular endothelial cells to induce bone formation. However, the mechanism of inducing blood vessels by bone-breaking cells is unknown. We performed an analysis using OPG-deficient mice with enhanced bone remodeling, and confirmed that in OPG-deficient mice, blood vessels increased and there were many bone-breaking cells in close proximity to the blood vessels. This suggests that there is a relationship between the increase in blood vessels caused by bone-breaking cells and the enhancement of bone remodeling.

Free Research Field

口腔解剖学

Academic Significance and Societal Importance of the Research Achievements

血管接着性の破骨細胞による血管を介した骨リモデリング調節メカニズムを解明することで、破骨細胞の血管を介した骨形成作用を応用した、代謝性骨疾患の新規治療法の提案に繋がる可能性がある。また、血管による骨再生機構の解明により、全身の組織再生に関する知見も提供することが想定され、血管新生のコントロールによる組織再生療法を目指した研究への展開などの波及効果がもたらされる。