Exploration of phospholipids as biomarkers for oral Potentially Malignant Disorders

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K18486
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57020:Oral pathobiological science-related
• Research Institution: Saitama Medical University
• Principal Investigator: Kawata Yumiko 埼玉医科大学, 医学部, 客員講師 (10348211)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 口腔潜在的悪性疾患 / 質量分析イメージング

Outline of Final Research Achievements

The presence and degree (grade) of histopathological epithelial dysplasia are the criterion standard used to valuating the risk of malignant transformation of oral potentially malignant disorders (OPMD)，but no valid biomarkers have been identified. The purpose of this study was to clarify the composition and distribution of phospholipids in each grade of OPMD using Mass spectrometry imaging, and to establish a new method for evaluating the grade of OPMD.
Although we tried to collect cases, it was difficult to reach the target number of cases due to circumstances such as the failure of the storage freezer. Unfortunately, the analysis has not been completed.

Free Research Field

口腔外科

Academic Significance and Societal Importance of the Research Achievements

本研究では，質量分析イメージング（mass spectrometry imaging；MSI）を用いて口腔潜在的悪性疾患 (Oral Potentially Malignant Disorders；OPMD)の各グレードにおけるリン脂質の組成変化と分布を明らかにし，OPMDのグレードを評価する新規手法を確立することを目的とした． 本研究によりOPMDのグレードを評価する新規手法が確立されれば，悪性化リスクをより正確に評価することが可能となり，個々の患者さんに合った適切な治療を行うことが可能となると考えられる．