The effect of resveratrol in mice periodontitis model

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K18500
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: Osaka University (2023); Tokyo Medical and Dental University (2020-2022)
• Principal Investigator: Ikeda Eri 大阪大学, 大学院歯学研究科, 助教 (40822565)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: レスベラトロール

Outline of Final Research Achievements

The antioxidant and anti-inflammatory effects of resveratrol have been reported previously. Particularly, monomeric trans-resveratrol has been demonstrated to produce positive effects in various pathological processes. We reported previously that resveratrol dimer-rich melinjo extract, among others, caused bone healing, decreased local oxidative damage, and activated antioxidants nuclear factor erythroid 2-related factor 2 (Nrf2) pathways in a mouse model of experimentally induced periodontitis (EP). EP was induced experimentally in mice by placement of a 9-0 silk ligature around the left second molar. Mice received 10 mg/kg of resveratrol dimer intraperitoneally on day 0 and 3 after induction of EP. We couldn't find any difference of helper T cell compositions in cervical lymph nods.

Free Research Field

歯周病学

Academic Significance and Societal Importance of the Research Achievements

レスベラトロールは抗酸化物質であり、抗炎症作用も有するポリフェノールである。レスベラトロールが歯周炎モデルマウスにおいて口腔免疫に与える影響を検討することで、レスベラトロールが炎症を緩和するメカニズム解明の一端になったと考えている。