Analysis the effect of antimicrobial peptide-containing liponanocapsules as the local drug delivery systems for periodontitis

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K18502
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: Niigata University
• Principal Investigator: Sato Keisuke 新潟大学, 医歯学総合病院, 助教 (80828905)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: ナノメディシン / リポナノカプセル / 抗菌ペプチド / 歯周病 / LDDS

Outline of Final Research Achievements

The existing Local Drug Delivery System for periodontal disease necessary to improve because of the spread of Antimicrobial resistance and change of social needs by the aging society. This study is aiming for develop the bionanocapsule include the antibacterial peptide and assess the function as the LDDS preparation.
The degradation rate of the fluorescent substance internal liponanocapsules were measured, suggesting the environmentally responsive degradation of the capsules, induced by the growth of the bacteria and the maturation of the biofilm. And it was suggested that antibacterial peptide have small effect for the gingival barrier function.
Further studies are needed that improve the capsules to take the stability and environment response.

Free Research Field

歯周病学

Academic Significance and Societal Importance of the Research Achievements

薬剤耐性菌の問題や社会的ニーズの変化を受けて、より長期にわたり薬物が局所に停留し徐放性が維持されかつ狭域スペクトルで安全性が高い、新規の歯周病治療用LDDS製剤の開発が必要とされている。本研究は歯周病治療に有効な付加価値を有する狭域スペクトル抗菌ペプチドに対して、リポナノカプセルをナノキャリアとして使用することで、長期徐放型LDDS製剤を目指すところに学術的新規性を有する。また、本研究により歯周病治療に有効な新規ナノメディシンとしての臨床応用が可能となれば、高齢化や薬剤耐性菌の蔓延拡大といった現代社会が抱える問題解決の一助となることから、その社会的意義は大きい。