Study on the homeostasis mechanism of MXRA5 in pulp tissue.

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K18511
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: Hiroshima University
• Principal Investigator: Yoshida Kazuma 広島大学, 医系科学研究科(歯), 助教 (60846856)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 歯髄 / 再生

Outline of Final Research Achievements

Dental pulp mesenchymal stem cells (DPSC) are expected to be applied to various tissue regeneration as a useful stem cell source due to their high proliferative ability and productivity. Furthermore, it has been reported that DPSCs have a higher cell proliferation ability than bone marrow-derived mesenchymal stem cells (BMMSCs). However, the mechanism by which DPSCs maintain high proliferative capacity remains unclear. In this study, we searched the NCBI GO analysis database to clarify the molecular basis of the high proliferative capacity of DPSCs.

Free Research Field

歯内療法学

Academic Significance and Societal Importance of the Research Achievements

歯髄間葉系幹細胞 (dental pulp stem cells: DPSC) はその高い増殖能や易回収性により、有用な幹細胞ソースとして様々な組織再生への応用が期待されている。さらに、DPSC は骨髄由来間葉系幹細胞(BMMSC: bone marrow stem cells) と比べて細胞増殖能が高いとの報告もある。しかしながら、DPSC が高い増殖能を維持する機構については十分に明らかとなっていない。その分子基盤を明らかにすることによって，DPSCの再生医療への適応が前進することになる。