2022 Fiscal Year Final Research Report
Ion-exchange treated zeolite-added calcium silicate cement for root canal treatment
| Project/Area Number |
20K18548
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57030:Conservative dentistry-related
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| Research Institution | Asahi University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | MTA / ケイ酸カルシウム化合物 / ケイ酸二カルシウム / ケイ酸三カルシウム / 根管充填剤 / ゼオライト / イオン交換 |
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| Outline of Final Research Achievements |
Mineral Trioxide Aggregate (MTA) is highly evaluated in root canal treatment, However, it is expensive and not widely used. In this study, we aimed to create a low-cost cement composed mainly of calcium silicate, the main ingredient of MTA, and to prepare a dental cement with enhanced antimicrobial properties by adding zeolite powder modified to release cations with desired effects, such as silver and zinc ions that exhibit antimicrobial properties through ion exchange treatment. The aim was to produce a dental cement with enhanced antimicrobial activity. We confirmed that the zeolite after ion exchange eluted the target metal ions. In addition, to evaluate the properties of synthetic calcium silicate, we attempted to synthesize two types of calcium silicate compounds here.
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| Free Research Field |
歯科保存学
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| Academic Significance and Societal Importance of the Research Achievements |
現在、歯内療法学分野で高い評価を得て注目されているMTAの適用拡大を目的とした研究やMTAに代わる代替材料の研究が盛んに行われている。MTAが高価であることが適用拡大を妨げる一因となっていることから、本研究ではMTAの成分の中核となるケイ酸カルシウムを試薬から合成し、さらにイオン交換を行ったゼオライトを添加することにより抗菌作用等の機能付与の可能性を示した。
このような新たな根管充填材料を安価に創出できれば歯の保存治療に大きな貢献をなすことができ国民のQOL向上につながると考えられた。
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