Analysis of osteogenesis mechanism by magnesium alloy

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K18551
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57040:Regenerative dentistry and dental engineering-related
• Research Institution: Tohoku University
• Principal Investigator: Odashima Kenji 東北大学, 歯学研究科, 非常勤講師 (60852770)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: マグネシウム / 生体内吸収性

Outline of Final Research Achievements

Mg had no adverse effect on wound healing; neoplastic bone formation was seen around Mg, with new bone surrounding magnesium at 8 weeks. TRAP staining and immunohistologic staining revealed TRAP-positive osteoclasts just below the specimen or on the bone surface. Type 1 collagen was found in the peri-graft and bone tissue. Osteopontin was identified in both groups, consistent with remodeling lines within new bone and existing bone. Osteocalcin was found in cells in the periosteal equivalent of the cortical bone surface and in the existing bone; TRAP-positive osteocytes were most common in the Mg group.

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Free Research Field

口腔外科

Academic Significance and Societal Importance of the Research Achievements

マグネシウムは、生体内吸収性でありながら骨形成を促進する可能性が示唆された。骨固定デバイスとして二次手術の必要性がないが、骨形成を促進することができるため骨折の際のプレートやインプラント手術時のスクリューへの応用が期待されると思われた。