Development of bioabsorbable membranes with bioactive functions by applying micro/nano-patterned structures

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K18568
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57040:Regenerative dentistry and dental engineering-related
• Research Institution: Fukuoka Dental College
• Principal Investigator: Kaga Naoyuki 福岡歯科大学, 口腔歯学部, 講師 (50824083)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: マイクロナノパターン / PLGA / ナノインプリント / メンブレン / 再生療法 / 骨芽細胞 / 上皮細胞 / 細胞接着

Outline of Final Research Achievements

By applying the thermal nanoimprinting method, it has become possible to fabricate bioabsorbable membranes with micro/nano-patterned structures on the surface of the biodegradable polymer Poly(lactic-co-glycolic acid) (PLGA).
It was shown that the application of micro/nano-patterns improved cell adhesion and proliferation in osteoblasts, while inhibited cell adhesion and proliferation in epithelial cells. This results were suggested the possibility that bioactive functions such as adhesion, morphology, and differentiation can be expressed on the absorbable membrane surface itself.

Free Research Field

Biomaterial

Academic Significance and Societal Importance of the Research Achievements

本研究により，再生療法で用いる吸収性メンブレンで細胞腫の接着・増殖・分化をコントロールできる可能性が示された。このことは，メンブレンの上皮側では上皮細胞の増殖を抑制し，骨欠損側では骨芽細胞の増殖と分化を促進することできる理想的なメンブレンの開発に繋がる一歩であり，社会的意義は大きい。