2021 Fiscal Year Final Research Report
Effect of local hypoxia due to uneven distribution of blood vessels on fibrogenesis of periodontal ligament
| Project/Area Number |
20K18594
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57050:Prosthodontics-related
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2022-03-31
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| Keywords | 歯根膜 / 歯根膜線維 / 部位特異性 / 低酸素 |
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| Outline of Final Research Achievements |
Understanding the tissue characteristics of the periodontal ligament (PDL) is essential for maintaining occlusal function. Previous studies have indirectly suggested that PDL cells are heterogeneous with site-specific characteristics, but their details and regulatory mechanisms remain unclear. In this study, we focused on the high maturity of PDL fibers in the vicinity of cementum, which has poor vascular structure. It is possible that collagenous fiber maturation caused by low oxygen produces site-specificity of the PDL. Understanding the site-specificity of the PDL is extremely important as basic information for biologically understanding the various clinical symptoms associated with prosthetic procedures.
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| Free Research Field |
歯科補綴学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は歯根膜組織における低酸素状態が線維形成に及ぼす影響を理解することであり，線維構造の検出と定量解析において一定の成果を得ることが出来た．補綴処置に付随して歯周組織に生じる臨床症状を生物学的に理解するための基礎的情報として，極めて重要であり臨床/学術的に高い意義を有している．
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