Risk genes involved in the development of temporomandibular joint osteoarthritis

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K18600
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57050:Prosthodontics-related
• Research Institution: Osaka University
• Principal Investigator: Takaoka Ryota 大阪大学, 大学院歯学研究科, 助教 (20733968)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 変形性顎関節症 / 遺伝的素因

Outline of Final Research Achievements

Genetic polymorphisms involved in the development of osteoarthritis (OA) in the knee and hip joints have been reported. There were no studies investigating OA in the polymorphisms In the temporomandibular joint. The present multivariate analysis clarified the association between the single nucleotide polymorphism (rs8044769) and TMJOA even after adjusting for the effects of age, gender, and disc dynamics abnormalities, which have been reported to have a strong association with TMJOA. It was suggested that the FTO gene may promote the development of TMJOA with the onset of disc disc displacement as a trigger. This study is the first study to suggest an association between TMJOA and specific single nucleotide polymorphisms.

Free Research Field

顎関節症

Academic Significance and Societal Importance of the Research Achievements

治療効果を左右し，変形性顎関節症の将来につながるリスク遺伝子の同定は，患者の遺伝的素因に合った最適の治療法を選択し，提供するための術前診断技術に繋がるものと期待される．さらに，変形性顎関節症の進行を加速させるをリスク遺伝子が明らかにされると，進行を予防するための治療薬が開発・立案されるための一助となる．今後，本研究の研究結果をもとに遺伝学的なアプローチによる研究が発展し，変形性顎関節症の術前のリスク診断を可能にするだけでなく，テーラーメイド治療の実現も可能になるのではないかと期待している．