Relationship between molecular weight of photopolymerizable crosslinkable vinyl ester and bone formation rate of porous absorbable bone grafting material

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K18602
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57050:Prosthodontics-related
• Research Institution: Okayama University
• Principal Investigator: Yamada Chie 岡山大学, 歯学部, 博士研究員 (60838001)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 骨補填材 / 吸収性 / 光重合 / ビニルエステル / アジピン酸ジビニル / BMP２

Outline of Final Research Achievements

The photopolymerization method can suppress heat generation during monomer polymerization. The osteogenic ability can be expected if a bone substitute made by photopolymerizing a monomer containing bone morphogenetic protein is decomposed. In this study, we observed the decomposition rate and amount of bone formation of bone substitute containing bone morphogenetic proteins by varying the amount of polymerization catalyst. Reducing the amount of polymerization catalyst decreased the amount of early bone formation, but the absorption rate of the bone substitute increased. It was indicated that it is possible to adjust the absorption rate of the bone substitute by changing the amount of polymerization catalyst.

Free Research Field

歯科補綴学

Academic Significance and Societal Importance of the Research Achievements

本研究で用いたジビニルエステルは，重合によって架橋構造を与えて強度を示すとともに生分解性を有し，光重合が可能である。骨形成蛋白は熱変性するため，光重合することで薬効を維持したまま重合体に含有することができる。本研究では重合触媒量を調整することで，重合体の分解速度を調整できることが示されたので，長期間の薬効を期待することが可能となる。