Periodontal Tissue Regeneration with Soft Tissue Sealing Implant Abutments

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K18622
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57050:Prosthodontics-related
• Research Institution: Fukuoka Dental College
• Principal Investigator: YANAGI AYAKO (佐藤絢子) 福岡歯科大学, 口腔歯学部, 医員 (70803998)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: インプラント / 細胞シート

Outline of Final Research Achievements

Dental implants are considered more susceptible to infection than natural teeth because their adhesive and protective capacities are weaker than those of periodontal tissues. Gingival defenses need to be enhanced to protect implants from infection from the surrounding area. In this study, we attempted to regenerate peri-implant periodontal tissue tissues using gingiva-derived epithelial cell sheets and lip-derived fibroblast cell sheets based on the cell sheet culture method. In addition, bone regeneration induction using DFAT cells was performed to obtain harmonious peri-implant tissues.

Free Research Field

補綴

Academic Significance and Societal Importance of the Research Achievements

本研究は細胞シートを応用した歯肉由来上皮細胞細胞および口唇由来線維芽細胞による軟組織再生とDFAT細胞を用いた骨再生により軟組織および硬組織を含めた歯周組織の再生を検討した。これらの再生によりインプラント周囲の生体を模倣した周囲組織の再生の可能性が示された。