Elucidation of onset mechanism of Dental metal allergy originating from the failure of immune tolerance

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K18627
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57050:Prosthodontics-related
• Research Institution: Niigata University
• Principal Investigator: Eguchi Kaori 新潟大学, 医歯学総合病院, 助教 (10779614)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 歯科金属アレルギー / 免疫寛容破綻 / モデルマウス

Outline of Final Research Achievements

I established a nickel allergy animal model and tried to clarify the site and mechanism of allergen entry by analyzing changes in intestinal permeability and intestinal immunity to clarify the site and mechanism of allergen entry. I also established an animal model of dental metal allergy with periodontal disease and verified the relationship between periodontal disease and dental metal allergy. As a result, it confirmed that the skin symptoms caused by dental metal allergy are exacerbated by the influence of periodontal pathogenic bacteria that suggesting a relationship between periodontal disease and dental metal allergy-related diseases. Further verification is required to identify the origin of the pathogenesis of dental metal allergy.

Free Research Field

歯科補綴学

Academic Significance and Societal Importance of the Research Achievements

本研究成果から、歯周病と歯科金属アレルギー関連疾患との関連性が示唆され、歯周治療によって歯科金属アレルギー関連疾患の症状を軽減できる可能性が示唆された。一方で、歯周病と歯科金属アレルギーの発症との関連についてはさらなる検証が必要である。金属補綴修復物と歯周病による免疫寛容の破綻が歯科金属アレルギー発症機序の起点になるか否かを明らかにし、金属の体内侵入経路とその機序を解明することは、治療標的を明らかにし、歯科金属アレルギー関連疾患の症状寛解に有効な歯科処置のエビデンス構築に貢献することができる。