2021 Fiscal Year Final Research Report
Basic research for the development of new treatments for Sjogren's syndrome via micro RNA
| Project/Area Number |
20K18671
|
|---|
| Research Category |
Grant-in-Aid for Early-Career Scientists
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Basic Section 57060:Surgical dentistry-related
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2020-04-01 – 2022-03-31
|
| Keywords | エクソソーム / 抗炎症作用 / マイクロRNA / シェーグレン症候群 / 歯髄幹細胞 |
|---|
| Outline of Final Research Achievements |
In recent years, it has been reported that exosomes (Exo) contained in conditioned media play an important role in cell-cell communication. It is expected that administration of Exo will bring about therapeutic effects such as anti-inflammatory action. Therefore, human bone marrow mesenchymal stem cell exosomes (BMMSC-Exo) and human dental pulp stem cell exosomes (DPSC-Exo) were administered to Sjogren's syndrome (SS) model mice, and the therapeutic effects were compared and examined.
The results showed that the group in which DPSC-Exo was administered to the experimental animals had higher salivary flow rate and decreased lymphocyte infiltration around the ductal cells. Therefore, it was suggested that administration of DPSC-Exo may be a new treatment for SS.
|
| Free Research Field |
歯科口腔外科、歯科領域における再生医療
|
| Academic Significance and Societal Importance of the Research Achievements |
シェーグレン症候群は、中年女性に好発する涙腺・唾液腺を標的とする自己免疫疾患であり、涙液・唾液の減少を引き起こす。現在までシェーグレン症候群に対する根治的治療法がないのが現状である。
ヒト歯髄幹細胞は他の幹細胞より豊富に免疫抑制効果のあるエクソソームを含んでいることがわかっている。そのエクソソーム中に抗炎症効果のあるマイクロ（mi）RNAが含まれており、現在までいくつか候補を絞っている。候補のmiRNAが病態抑制効果に関与しているかをさらに検証し、制御している遺伝子やタンパク質を同定することで、創薬研究につなげることができると考えている。
|
