Construction of a prognostic prediction system for oral cancer intra-arterial infusion chemoradiotherapy based on pathological features and blood circulating nucleic acids

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K18705
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Yokohama City University
• Principal Investigator: HAYASHI Yuichiro 横浜市立大学, 医学研究科, 客員研究員 (80806464)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: Oral cancer

Outline of Final Research Achievements

A surgical resection is the first-choice treatment for oral cancer, and in the case of early-stage cancer, a complete cure can be expected. However, the postoperative dysphagia and deterioration of esthetics become problems when a large lesion is resected. In addition, in the case of advanced cancer, there are some cases of the recurrence or metastasis after the surgical resection.intra-arterial infusion chemotherapy concurrent with radiotherapy (IACRT) for oral cancer shows a high therapeutic effect in advanced cases and the elderly, but there are also treatment-resistant and recurrent cases. Therefore, it is desired to develop a technique for determining the therapeutic response for IACRT. The purpose of this study is to establish a system, which detects the therapeutic effect by focusing on histopathological features and blood cell free RNA.

Free Research Field

Head and neck cancer

Academic Significance and Societal Importance of the Research Achievements

超高齢社会において、口腔癌の罹患率、死亡率は増加傾向にある。口腔癌の標準治療は外科的切除であるが、術後の機能・整容の温存が問題となる。近年は全身化学療法の開発も進み広く利用されているが、有害事象の発生を伴うことも多い。我々は、非手術療法として動注の開発とその有用性の検討を行ってきた。病変を切除せずに進行癌に対して高い治療効果が期待できることを報告している一方で、再発症例や治療効果が乏しい症例も存在する。
本研究は、動注施行前後の病理組織学的な検討や治療反応性を判定するシステムの開発を目指した。本研究成果は、より効果的で安全に動注を行う基盤構築へつながる。