Establishment of Oral Application Criteria

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K18708
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Osaka Medical and Pharmaceutical University
• Principal Investigator: Matsumura Mayumi 大阪医科薬科大学, 医学部, 非常勤医師 (60711273)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: 閉塞性睡眠時無呼吸 / 口腔内装置 / 口腔機能

Outline of Final Research Achievements

To investigate the relationship between oral function and respiratory disturbance index (RDI). This has not been reported previously. Sixty-one patients (41 males, 20 females) who were treated for obstructive sleep apnea with an oral appliance were enrolled in this study. Mean age and body mass index were 55.5±12.7 years and 24.4±4.0 kg/m2, respectively. Patients were classified into groups based on body mass index (non-obese group, < 25.0 kg/m2 and obese group, ≧ 25.0 kg/m2) and severity of RDI (mild group 5≦RDI < 15 and moderate and severe group RDI >15). RDI was measured by portable monitoring and oral function was measured as maximum occlusal force, tongue pressure and labial closure force. A significant negative correlation was found between labial closure force and RDI in the total cohort and in non-obese cases (P<0.05).
This study suggests that labial closure force may affect sleep-disordered breathing.

Free Research Field

歯科

Academic Significance and Societal Importance of the Research Achievements

閉塞性睡眠時無呼吸に罹患する患者は非常に多いが、様々な要因が関与して発症するため、未だ病態など不明な点が多い。本課題で口唇閉鎖力と睡眠時の呼吸障害との関連が明らかになったことから、今後は閉塞性睡眠時無呼吸の新たな治療方法の開発や治療方法の選択基準の確立につながると考えられる。