IRelationship between oral microbiota and chemotherapy-induced oral mucositis.

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K18713
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Osaka Medical and Pharmaceutical University
• Principal Investigator: Ochi Ayako 大阪医科薬科大学, 医学部, 非常勤医師 (40846903)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 口腔粘膜炎 / 口腔細菌叢 / 化学療法 / 造血器悪性腫瘍

Outline of Final Research Achievements

Oral microbiota may be associated with serious local or systemic medical conditions resulting from chemotherapy. This study was conducted to evaluate the changes in the oral microbiota following the initiation of chemotherapy in patients with hematopoietic malignancies and to identify the characteristics of the oral microbiota associated with oral mucositis. We characterized the oral microbiota associated with the initiation of chemotherapy in patients with hematopoietic malignancies. In addition, our findings suggest that oral microbiota composition before the start of chemotherapy may be associated with oral mucositis. The results of this study emphasize the importance of oral management focusing on the oral microbiota during chemotherapy in patients with hematologic malignancies.

Free Research Field

口腔外科学

Academic Significance and Societal Importance of the Research Achievements

造血器悪性腫瘍患者における化学療法の開始に伴う口腔細菌叢の変化を特徴づけた。さらに，口腔粘膜炎に関連する口腔細菌叢の特徴を明らかにした。本研究の結果は，口腔粘膜炎のような化学療法に伴う有害事象の病態を理解するためには，口腔細菌叢に注目することが重要であり，造血器悪性腫瘍患者における化学療法開始前後の口腔細菌叢変化に着目した口腔管理の可能性を示唆するものである。これらの知見は，化学療法を受ける患者の有害事象の予測，予防，改善に大きく貢献するものと考えられる。