2023 Fiscal Year Final Research Report
A method to promote healing after free flap reconstruction using dental pulp stem cell-derived factors and a semiconductor laser
| Project/Area Number |
20K18720
|
|---|
| Research Category |
Grant-in-Aid for Early-Career Scientists
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Basic Section 57060:Surgical dentistry-related
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2020-04-01 – 2024-03-31
|
| Keywords | 歯髄幹細胞 / 組織修復 / 組織再生 / 虚血再灌流傷害 |
|---|
| Outline of Final Research Achievements |
Using a mouse dorsal flap ischemia-reperfusion injury model, we demonstrated the effect of dental pulp stem cell conditioned medium on increasing the blood flow to the flap and reducing the necrotic area. The therapeutic mechanism was thought to be the multifaceted effects of dental pulp stem cell conditioned medium, including cytoprotection, anti-apoptosis, anti-inflammation, and anti-oxidative stress.
|
| Free Research Field |
oral and maxillofacial surgery
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究では歯髄幹細胞由来因子による皮弁再建後の治癒促進法の可能性を提示した。新たな治療法が確立されることで、大掛かりな設備を必要とせず、費用のかからない新たな組織再生・修復が可能になる。この方法は皮弁生着を改善させるという目的に使用できるだけでなく、組織の再生・修復過程にあるあらゆる病態において応用でき、さまざまな創傷治癒、再生医療における普遍的な治療法を提供するものと考えられる。
|
