2021 Fiscal Year Final Research Report
Evaluation of antitumor effect by TGF-b inhibition in oral cancer microenvironment
| Project/Area Number |
20K18721
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57060:Surgical dentistry-related
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2022-03-31
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| Keywords | TGF-β / 口腔癌の転移 |
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| Outline of Final Research Achievements |
Cervical lymph node metastasis is one of the poor prognostic factors in oral cancer, especially tongue cancer, and elucidation of its mechanism is important in the diagnosis, treatment, and prognosis control of tongue cancer. It is known that epithelial mesenchymal transition (EMT) of cancer cells is involved in cancer infiltration and metastasis, and that EMT is exhibited by stimulating cells with TGF-β (Transforming growth factor-β). In this study, we have investigated factors related to EMT of cells during TGF-β stimulation.
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| Free Research Field |
口腔外科
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| Academic Significance and Societal Importance of the Research Achievements |
現在口腔癌に対して外科治療、放射線療法、化学療法を併用して行うが、局所進行症例や一次治療後の再発転移症例においては既存の治療法ではコントロール不良となることも多い。口腔癌の頚部リンパ節転移において、EMTが深く関与していると言われているが、その細胞周期について詳細に調べることで、なぜ頚部リンパ節転移が予後不良につながるか、またその結果に直接寄与している因子が何であるか解明することは、口腔癌の治療法の開発や頸部リンパ節転移のメカニズムの解明につながると期待される。
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