Elucidation of tumor microenvironment in advanced areas of oral cancer development and application to treatmen

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K18732
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Sapporo Medical University
• Principal Investigator: SHIMIZU SHOTA 札幌医科大学, 医学部, 研究員 (90792127)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: Tumor Budding / 腫瘍浸潤発育先進部 / 予防的頸部郭清術

Outline of Final Research Achievements

This research focuses on 1) tumor budding in the local microenvironment of cancer growth, and 2) analysis of genetic and epigenetic abnormalities in cadherin-catenin and epithelial-to-epithelial abnormalities in oral cancer. This is a basic research aimed at applying to treatment by elucidating the actual state and interrelationship of the expression of leaf transition (EMT) and 3) lymphoid cell infiltration. Furthermore, in order to investigate this relationship, it is necessary to search for immune checkpoints in the area of cancer growth. In this study, we will attempt to elucidate the tumor microenvironment based on the above hypothesis.

Free Research Field

口腔癌

Academic Significance and Societal Importance of the Research Achievements

本研究は、口腔癌細胞の遊離・浸潤・転移に関与する細胞接着分子であるカドヘリン-カテニン複合体、癌の形質転換に関与するβ-カテニンのジェネティック・エピジェネティックな異常の発現、細胞内シグナル伝達経路に関与する複数の機能分子、癌細胞の形質転換に反応して浸潤する 複数の組織内リンパ系細胞の抗体パネルにより、口腔癌の腫瘍微小環境を解明し、臨床病理学的因子との相関を詳細に検討することで治療への応用を目指すことを目的とする。