The autocrine mechanism of suprabasin via TPD52 family proteins

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K18738
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Showa University
• Principal Investigator: Miyamoto Saya 昭和大学, 歯学部, 助教 (60867737)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 口腔扁平上皮癌 / 低酸素 / スプラバシン / 血管新生 / 細胞浸潤 / アポトーシス / オートファジー

Outline of Final Research Achievements

We discovered Suprabasin (SBSN) as a secreted protein that binds to TPD52, a protein specific to oral squamous cell carcinoma cells (OSCC), and is transported outside the cells. SBSN is a secreted protein identified in epithelial cells such as the esophagus and skin, and is known to play an important role in the proliferation and metastasis of oral squamous cell carcinoma cells. Therefore, in this study, we investigated the expression and function of SBSN in oral squamous cell carcinoma cells under hypoxia. The results revealed that SBSN is involved in cell death resistance in hypoxic OSCC by inducing cell invasion and angiogenesis rather than inducing autophagy.

Free Research Field

口腔外科学

Academic Significance and Societal Importance of the Research Achievements

低酸素下の口腔扁平上皮癌細胞においては, SBSNは細胞浸潤, 血管新生に重要な役割を果たすことが明らかとなった。この知見は口腔扁平上皮癌に対する化学療法において、新たな分子標的薬のターゲットを見出したことを意味する。ゆえに、本研究は口腔がん治療における一つのマイルストーンになることが期待される。