Investigation of inhibitory effect and mechanism of daidzein on bone resorption in middle-aged orthodontic patients.

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K18793
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57070:Developmental dentistry-related
• Research Institution: Nihon University
• Principal Investigator: SHIMIZU Mami 日本大学, 松戸歯学部, 助教 (50732856)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: Daidzein / 壮年期 / 後戻り

Outline of Final Research Achievements

The results of this study showed that the expression of RANKL, a bone resorption factor, decreased and OPG increased on the compression side where Daidzein (DZ) was administered after applying tensile force to osteoblasts. On the tension bone-forming factors, increased. In addition, bone mineral density and bone trabecular volume fraction increased in the DZ-treated group after tooth movement in ovariectomized (OVX) rats, and the rate of retroversion decreased.
These results suggest that the addition of DZ to osteoblasts under orthodontic stress suppresses bone resorption and promotes bone formation. In addition, administration of DZ to the OVX group after orthodontic treatment may suppress relapse. These results suggest that DZ is effective in preventing relapse after orthodontic treatment in middle-aged patients.

Free Research Field

矯正歯科学

Academic Significance and Societal Importance of the Research Achievements

本研究の結果から矯正力を負荷した後, 骨芽細胞にDZを添加することで骨吸収が抑制され骨形成が促進された。さらにOVX群に矯正歯科治療後にDZを投与することで骨密度, 骨梁体積率が増加した。これらのことより矯正歯科治療後にDZを添加することにより圧迫側で破骨細胞の分化を抑制し骨吸収を減少させ, 牽引側では骨形成を促進することで, 歯槽骨のリモデリングを早期に安定させ後戻りを抑制する可能性が示唆された。また骨量が減少して後戻りリスクの高い, 壮年患者にもDZをサプリメントなどの形で動的治療終了時から服用させることで, 保定期間を短縮化できる可能性があり意義あるものとなった。