2023 Fiscal Year Final Research Report
Mechanism of taste disorder induced by radiotherapy and the process of recovery
| Project/Area Number |
20K18807
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57080:Social dentistry-related
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 味覚障害 / 放射線治療 |
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| Outline of Final Research Achievements |
This research investigated the mechanism of radiation-induced taste disorder and its recovery process in patients undergoing radiotherapy. Based on data from 10 patients who underwent brachytherapy for tongue cancer, the duration of taste recovery after brachytherapy was 284 days for sweet taste, 308 days for umami taste, and 308 days for bitter taste. Regarding taste receptor expression, immediately after brachytherapy, all taste receptors for sweet, umami, and bitter tastes were more highly expressed on the brachytherapy side of the tongue, but thereafter, the difference in taste receptor expression between the radiotherapy and non-radiotherapy sides of the tongue showed a tendency to decrease over time.
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| Free Research Field |
歯科放射線学
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| Academic Significance and Societal Importance of the Research Achievements |
今回の研究では、舌癌に対して小線源治療を受けた患者を対象として、放射線治療による味覚障害についてその発症メカニズムと回復過程について調査を行った。今回の研究結果から放射線治療後、約300日程度で味覚は回復することがわかった。味覚障害について細胞レベルでの調査も行ったが、味覚障害のメカニズムを解明できるだけのデータは得られなかった。
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