Relationship between Helicobacter pylori in oral cavity and lifestyle factors

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K18809
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57080:Social dentistry-related
• Research Institution: Asahi University (2021); Kyoto Prefectural University of Medicine (2020)
• Principal Investigator: iwai komei 朝日大学, 歯学部, 助教 (20847214)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: Helicobacter pylori感染 / 齲蝕 / 尿中抗体検査 / 横断的研究

Outline of Final Research Achievements

We investigated the association between Helicobacter pylori infection (H. pylori) and dental disease in 210 participants (117 males and 93 females) scheduled for pulp removal treatment. The results showed that the prevalence of H. pylori infection was 14%. In addition, H. pylori-infected participants had a higher proportion of decayed teeth than non-infected participants (p<0.05). Logistic analysis showed that H. pylori infection was positively associated with presence of decayed teeth (OR: 3.717, 95% CI: 2.292 to 6.026). Furthermore, the prevalence of H. pylori infection increased with number of decayed teeth (p< 0.05).

Free Research Field

公衆衛生学

Academic Significance and Societal Importance of the Research Achievements

未だに詳細が不明なH. pyloriにおいて、口腔疾患とH. pyloriの関連を明らかにした。
つまり、齲蝕の集中的な治療や予防により口腔内及び胃内におけるH. pyloriの菌数が減少し、胃粘膜の炎症の軽減や萎縮性胃炎、胃潰瘍、胃がんの発症の減少に寄与する可能性がある。