Incidence and Risk Factors of Pertussis in the Urban and Remote areas in Vietnam

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K18905
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 58020:Hygiene and public health-related: including laboratory approach
• Research Institution: Nagasaki University
• Principal Investigator: Toizumi Michiko 長崎大学, 熱帯医学研究所, 准教授 (00778623)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 百日咳 / seroprevalence / ワクチン

Outline of Final Research Achievements

The prevalence of recent pertussis infection and its associated factors were estimated in urban and remote areas of Vietnam. In the urban area of Nha Trang, the prevalence of pertussis infection within the past 12 months was 9.6%, 5.6%, 6.7%, 2.1%, and 3.8% for ages 3-5, 6-15, 16-25, 26-35, and 36-55, respectively. In the remote Quang Ngai, the rates ranged from 7.2% to 11.4%. Cough, antibiotic use within two weeks, smoking, history of diagnosis of pertussis, and persistent cough with paroxysmal cough were positively associated with pertussis infection within 12 months. B. pertussis was not detected in any nasopharyngeal swab. B. pertussis circulates in all age groups in the urban and remote areas of Vietnam. Continuous and standardized surveillance is required in the future.

Free Research Field

小児感染症学

Academic Significance and Societal Importance of the Research Achievements

本研究は、百日咳菌がベトナムの都市部および遠隔地で、幅広い年齢層、特に年長児、思春期年齢、若年成人で循環していることを明らかにし、乳幼児を百日咳から守るためには、現行のDPTワクチン4回接種の強化に加え、就学前・学童期の小児における追加ブースターワクチン導入で循環を抑制する必要性を示唆した。また、よりよい予防策を検討するため、継続的かつ標準化されたサーベイランスの重要性を強調した。