2021 Fiscal Year Final Research Report
Relationship between prognosis of life and carotid thickening in people who measured both ADMA and homocysteine
| Project/Area Number |
20K18945
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2022-03-31
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| Keywords | ホモシステイン / ADMA |
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| Outline of Final Research Achievements |
Homocysteine and ADMA are recognized as risk factors for arteriosclerosis. A total of 517 subjects were recruited from a population-based survey in 1999 in Tanushimaru, and we measured fasting plasma Homocysteine and ADMA levels. We followed them up for over 20 years and examined the effect on mortality using Cox proportional hazard regression model. Homocysteine and ADMA were divided quintiles. In the Homocysteine and ADMA quintiles, we calculated the Hazard ratio of all-cause death using the lowest quintile as the reference. in the Homocysteine quintiles, Hazard ratio was significantly higher in the group with the highest homocysteine than in the group with the lowest homocysteine after adjusted for age and sex. But No significance was found for ADMA. we created the hierarchical model by division of Homocysteine and ADMA into quintiles.
this model showed the greater effect of combined Homocysteine and ADMA levels on all-cause death rather than Homocysteine or ADMA alone.
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| Free Research Field |
疫学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の結果ではホモシステインの上昇は全死亡に対する有意なリスク上昇を認めたが、ADMAに関しては単独での有意な関連は得られなかった。しかし、死亡に対するホモシステインとADMAの相乗効果が示唆された。現在、臨床においてADMAとホモシステインの定期的な測定は行われていないのが現状であるが、ADMA、ホモシステインを測定し、それらに対する介入を行う事で将来的な死亡リスクを低下させる可能性がある。
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