2023 Fiscal Year Final Research Report
Association between placental weight and birthweight ratio and childhood lifestyle-related diseases
Project/Area Number |
20K18963
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
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Research Institution | Kochi University |
Principal Investigator |
Mitsuda Naomi 高知大学, 医学部附属病院, 医員 (30611389)
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Project Period (FY) |
2020-04-01 – 2024-03-31
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Keywords | 胎盤重量 / 小児生活習慣病 / DOHaD / エコチル調査 |
Outline of Final Research Achievements |
The aim of study was to investigate whether placental weight/birth weight ratio (PW/BW ratio) are useful markers of the fetal prenatal environment and, consequently, that PW/BW ratio are also associated with childhood growth and development and risk of lifestyle-related diseases. During study period, we showed positive association between maternal smoking during pregnancy and PW/BW ratio, a U-shaped relationship between maternal hemoglobin concentration during pregnancy and PW/BW ratio, and positive association between maternal LDL cholesterol levels during pregnancy and PW/BW ratio. Furthermore, higher PW/BW ratio was associated with increased risk of neurodevelopmental delay at 3 years old.These results were published in papers and presented at conferences.
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Free Research Field |
小児科
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Academic Significance and Societal Importance of the Research Achievements |
PW/BW比は国内で生まれたほぼ全ての子どもで算出可能なマーカーである。本研究により、PW/BW比が子どもの将来の発育や健康状態に影響するマーカーとなることが立証でき、それによりPW/BW比の重要性が社会的評価を獲得すれば、PW/BW比を子どもの生活習慣病予防への早期介入にも広く活用できる。
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