Association Between Physical Activity Trajectory and Incidence of Dementia in Community-Dwelling Older Adults with Mild Cognitive Impariment

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K18975
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: Tohoku University (2022-2023); National Center for Geriatrics and Gerontology (2020-2021)
• Principal Investigator: Ippei Chiba 東北大学, 東北メディカル・メガバンク機構, 助教 (20835897)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 認知症 / 身体活動 / 地域在住高齢者

Outline of Final Research Achievements

This study examined the association between over 3-year longitudinal trajectory of domain-specific physical activity (e.g. steps, light intensity physical activity, and moderate-to-vigorous intensity physical activity) measured via accelerometer and the incidence of dementia for community-dwelling older adults with mild cognitive impairment.
Each domain of physical activity was categorized into two groups according (active group and inactive group) to the trajectory. In the multivariable-adjusted analysis, no apparent associations were found between each domain of physical activity and incidence of dementia. However, incidence of dementia was notably lower in the active group for steps and moderate-to-vigorous physical activity.

Free Research Field

疫学

Academic Significance and Societal Importance of the Research Achievements

今後も有病率の増加が予想される認知症において、非薬物的介入の確立は重要であり、身体活動の促進はその一つとして注目されている。さらに、本研究の対象である軽度認知障害は認知症発症の前段階であり、重要な予防介入のターゲットである。本研究では特に高い負荷の身体活動が保たれた集団において認知症発症は少ない傾向が見られた。今後のハイリスク者に対する身体活動促進を用いた認知症予防戦略に寄与しうる結果と考えられる。