Research on the establishment of a new preventive approach to cerebrovascular disease

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K19312
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Kagoshima University
• Principal Investigator: Otsuka Shotaro 鹿児島大学, 医歯学総合研究科, 特任助教 (80849901)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: RIPC / リハビリテーション医学 / 予防医学 / 神経保護効果 / 脳梗塞 / 予防運動 / preconnditioning

Outline of Final Research Achievements

An experiment was conducted to establish a remote ischemia preconditioning (RIPC) intervention method. Cuffs were placed on both thighs of rats and several combinations of ejection and release times were examined to determine the most effective combination. The results showed that two combinations, 5 min compression-10 min release and 10 min compression-10 min release, were found to be effective.　Furthermore, RIPC was found to induce neurotrophic factor and inhibit neuronal cell death. The duration of the neuroprotective effect induced by preconditioning exercise was also examined, and it was found that the effect lasted approximately 2 weeks after 3 weeks of preconditioning exercise.

Free Research Field

リハビリテーション医学

Academic Significance and Societal Importance of the Research Achievements

今回、寝たきりになる主な原因である脳梗塞に対しての新規の予防法の確立を目的に研究を行った。遠隔虚血プレコンディショニング（Remote limb ischemic preconditioning: RIPC）は、強力な神経保護効果を獲得することが出来るが、その方法は確立されていない。そこで、本研究では、介入方法の検討を行った。結果として、駆血時間よりも解放時間が重要である可能性が示せた。本研究をさらに前進させていくことによって、予防医学の発展や高齢者の寝たきりを減少させる解決の糸口になる可能性があり、社会的意義は大きい。