2022 Fiscal Year Final Research Report
mechanism elucidation of exercise effects to hereditary cystic kidney and liver desesase
| Project/Area Number |
20K19338
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 59010:Rehabilitation science-related
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | リハビリテーション / 多発性嚢胞腎 / 多発肝嚢胞 |
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| Outline of Final Research Achievements |
The cyst-suppressive and organ-protective effects of chronic exercise on hereditary cystic kidney/liver disease and the mechanism were investigated long-term exercise in PCK rats: autosomal dominant polycystic kidney disease model rats. As a result, inhibition of renal and hepatic cysts, hepatic and renal fibrosis, glomerular injury and renal tubular injury was clarified. Suppression of cell growth factors such as cAMP/B-Raf/ERK pathway and mTOR/S6 pathway, and activation of AMPK in the liver may be involved in the mechanism.
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| Free Research Field |
リハビリテーション医学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究において、腎・肝嚢胞疾患に対する運動療法の効果として、PCKラットへの長期的運動の腎・肝嚢胞抑制効果を世界で初めて報告した。その機序としてcAMP/B-Raf/ERK経路とmTOR/S6経路の抑制、肝ではAMPKの活性化が関与している可能性が考えられた。今後、腎・肝嚢胞疾患に対する運動療法のさらなる機序を解明することや運動療法と薬剤併用効果の検討により、遺伝性嚢胞性腎・肝疾患患者の臓器保護やそれに伴うQOLの維持、また新規治療への発展に役立つ可能性がある。
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