Impact of L-carnitine replacement therapy on functional recovery in patients with cognitive and behavioral dysfunction.

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K19427
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Jikei University School of Medicine
• Principal Investigator: Hada Takuya 東京慈恵会医科大学, 医学部, 助教 (10794943)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 高次脳機能障害 / カルニチン欠乏症

Outline of Final Research Achievements

Cognitive and behavioural disorders may be sequelae of brain damage due to brain disease or trauma. It is known to present with a variety of symptoms, including memory disorders, attention disorders, executive dysfunction and social and behavioural disorders, but there is still no fundamental treatment for these disorders. This study focused on carnitine replacement therapy as a new treatment for cognitive and behavioural disorders. Although no patients in the present study presented with carnitine deficiency and supplementation therapy was not implemented, further research will continue to investigate the effectiveness of carnitine replacement therapy for cognitive and behavioural disorders.

Free Research Field

リハビリテーション医学

Academic Significance and Societal Importance of the Research Achievements

本研究では高次脳機能障害者の脳の血流の変化と症状や紙面での検査結果の推移を調査し、検討を行った。症状や検査結果の改善と脳の血流の改善について一定の相関があることがわかり、新たな知見として学術誌へ論文として投稿し、掲載された。