The role of commissural fibers in the recovery after ischemic stroke

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K19446
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Osaka University
• Principal Investigator: Nakanishi Toru 大阪大学, 大学院医学系研究科, 特任助教(常勤) (00848492)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 脳梗塞 / 交連線維

Outline of Final Research Achievements

Inflammation after ischemic stroke induces cell death in neurons around the infarct core, leading to expansion of the infarct area. Therefore, it is important to clarify the regulatory mechanism of inflammation after ischemic stroke in order to develop effective therapies. In this study, I examined the role of commissural fibers from the non-infarcted hemisphere in the expansion of infarct area. Using the mouse model of ischemic stroke, I artificially suppressed neural activity in the non-infarcted hemisphere and found no change in the size of the infarcted area. In the future, it will be necessary to examine conditions for the creation of the ischemic stroke model mice and the timing of manipulation of neural activity.

Free Research Field

リハビリテーション

Academic Significance and Societal Importance of the Research Achievements

今後、非梗塞半球や交連線維の神経活動の操作によって、脳梗塞後の炎症を抑制できることが明らかになれば、非梗塞側半球が脳梗塞後の機能回復に関与するメカニズムの一端を解明することができると考える。また、非梗塞側半球への有効な経頭蓋磁気刺激方法の開発など、脳梗塞後の新たなリハビリテーション戦略の確立に向けた科学的根拠となることが期待できる。