The role of microRNA in the mechanism of bone mass maintenance

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K19513
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: Nihon Pharmaceutical University
• Principal Investigator: Agata Umon 日本薬科大学, 薬学部, 准教授 (30809132)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 骨代謝 / 運動 / 食事

Outline of Final Research Achievements

The purpose of this study was to examine whether exercise that results in changes in bone mass affects microRNA expression and how differences in the type, intensity, and duration of exercise affect the mechanism of microRNA expression.We confirmed that there are changes not only in bone mineral density but also in bone quality depending on the exercises. These changes were also confirmed by differences in food intake.We have succeeded in extracting total RNA, including small RNA, from femur and tibia regardless of differences in exercise or food intake, and we plan to continue our studies to elucidate the mechanism of bone mass maintenance.

Free Research Field

運動生理学

Academic Significance and Societal Importance of the Research Achievements

閉経後に顕著に表れる骨量低下や、骨折による寝たきり状態を予防および治療を行うことは重要な課題となっているが、骨量維持において骨代謝に関連した様々な細胞や分子間の相互作用が重要であることは自明である。本研究では運動の違いや食事摂取の違いによって変化する骨密度や骨質を検討し、それらの骨サンプルからmicroRNAの抽出を行っており、新たな骨量維持および改善における治療法あるいは予防法を確立するための基礎的知見として重要な意義があると考える。