The elucidation the mechanism through which exercise improves adipose tissue metabolism

2021 Fiscal Year Research-status Report

• Project/Area Number: 20K19532
• Research Institution: Department of Clinical Research, National Hospital Organization Kyoto Medical Center
• Principal Investigator: 二連木 晋輔 独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 研究員 (70741156)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 褐色脂肪組織 / 運動 / 寒冷曝露 / リピドミクス / オキシリピン

Outline of Annual Research Achievements

大学運動部および一般大学生を対象にリピドミクス測定および褐色脂肪組織の測定を行った。
興味深いことに、褐色脂肪組織活性の高い大学運動部の学生は寒冷曝露後の血中オキシリピンレベルが高値であった。
次に、マウスを対象に、運動後および寒冷曝露お後に、褐色脂肪組織のリピドミクスおよび遺伝子発現解析を行った。その結果について、3つの国際学会で発表を行う。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

データをまとめ３つの国際学会で発表を行う。

Strategy for Future Research Activity

国際学会にて発表を行い、フィードバックを得る。
それを踏まえて論文執筆に勤める。

Causes of Carryover

COVI19により国際学会に参加することができなかった。2022年度に３回国際学会で発表を行う。

Research Products

• [Int'l Joint Research] オハイオ州立大学(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: オハイオ州立大学
• [Journal Article] Association of serum fibroblast growth factor 21 with diabetic complications and insulin dose in patients with type 1 diabetes mellitus (2022)
  • Author(s): Taniguchi H, Nirengi S, Ishihara K, Sakane N.
  • Journal Title: PLoS One Volume: 17 Pages: e0263774.
  • DOI: 10.1371/journal.pone.0263774.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of Prolonged Sitting with or without Elastic Garments on Limb Volume, Arterial Blood Flow, and Muscle Oxygenation (2022)
  • Author(s): Yuko Kurosawa, Shinsuke Nirengi, Izumi Tabata, Tadao Isaka, Joseph F Clark, Takafumi Hamaoka
  • Journal Title: Med Sci Sports Exerc Volume: 54 Pages: 399-407.
  • DOI: 10.1249/MSS.0000000000002822.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Hepcidin-25/Ferritin Ratio Is Increased in University Rugby Players with Lower Fat Mass (2021)
  • Author(s): Nirengi S, Fujibayashi M, Furuno S, Sukino S, Suganuma A, Kawaguchi Y, Kawase Y, Kotani K, Sakane N.
  • Journal Title: Nutrients Volume: 13 Pages: 2993
  • DOI: 10.3390/nu13092993.
  • Peer Reviewed / Open Access
• [Journal Article] Diurnal variations of brown fat thermogenesis and fat oxidation in humans (2021)
  • Author(s): Matsushita M, Nirengi S, Hibi M, Wakabayashi H, Lee SI, Domichi M, Sakane N, Saito M.
  • Journal Title: Int J Obes (Lond) Volume: 45 Pages: 2499-2505
  • DOI: 10.1038/s41366-021-00927-x.
  • Peer Reviewed / Open Access
• [Journal Article] Front Nutr (2021)
  • Author(s): Nirengi S, Taniguchi H, Ishibashi A, Fujibayashi M, Akiyama N, Kotani K, Ishihara K, Sakane N.
  • Journal Title: Comparisons Between Serum Levels of Hepcidin and Leptin in Male College-Level Endurance Runners and Sprinters Volume: 8 Pages: 657789
  • DOI: 10.3389/fnut.2021.657789.
  • Peer Reviewed / Open Access
• [Journal Article] Lower bone mineral density and higher bone resorption marker levels in premenopausal women with type 1 diabetes in Japan (2021)
  • Author(s): Yoshioka F, Nirengi S, Murata T, Kawaguchi Y, Watanabe T, Saeki K, Yoshioka M, Sakane N.
  • Journal Title: J Diabetes Investig Volume: 12 Pages: 1689-1696
  • DOI: 10.1111/jdi.13530.
  • Peer Reviewed / Open Access
• [Presentation] 燃える脂肪組織 - 褐色脂肪組織 - を活性化して体脂肪を減らすには? (2021)
  • Author(s): 二連木晋輔
  • Organizer: 摂大農学セミナー
  • Invited