2022 Fiscal Year Final Research Report
Analysis of the fracture healing process in experimental model of periodontal disease
| Project/Area Number |
20K19546
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 59020:Sports sciences-related
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 骨折治癒過程 / 歯周病 |
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| Outline of Final Research Achievements |
Periodontal disease is a chronic inflammatory condition that induces systemic inflammation through the circulatory system. However, the impact of periodontal disease on fracture healing remains unclear. In this study, we investigated the influence of periodontal disease on the healing of metaphyseal and diaphyseal fractures using a mouse model of periodontal disease. On day 7, in the periodontal group, medullary callus formation was less than in the control group. However, there were no significant differences between the periodontal disease model group and the control group. Furthermore, on day 14, there were no significant differences in medullary callus formation or bone mineral density at the fracture site. These findings indicate that periodontal disease does not inhibit the healing processes of metaphyseal and diaphyseal fractures in mice.
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| Free Research Field |
骨折治癒過程
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| Academic Significance and Societal Importance of the Research Achievements |
歯周病は慢性炎症疾患である。スポーツ選手がスポーツドリンクの摂取量が多いため、歯周病の発症率が高いことが報告されている。骨折の発生率も高いため、歯周病が骨折治癒に与える影響を解明することは重要な課題である。リウマチなどの慢性炎症疾患では骨折治癒は遅延することが報告されている。本実験の結果から、血中の炎症マーカーが上昇しないレベルの歯周病モデルでは、骨折治癒過程に大きな影響がないことが明らかとなった。これらの結果から、口腔内を管理し、全身性の炎症を引き起こさないような環境を維持することが重要であると考えられた。
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