2022 Fiscal Year Final Research Report
A triglyceride metabolism by exercise through apolipoprotein C2 pathway
Project/Area Number |
20K19559
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 59020:Sports sciences-related
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Research Institution | Fukuoka University |
Principal Investigator |
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | 中性脂肪 / 運動 / 骨格筋 / アポリポ蛋白C2 |
Outline of Final Research Achievements |
This study using C2C12 mouse myoblastoma cells, human iPS cell-derived myocytes and skeletal muscle from wild-type C57BL6J mice, revealed the existence of apolipoprotein C2 in skeletal muscle. Interestingly, in vivo study using wild-type mice showed that the plasma triglyceride level was decreased and apolipoprotein C2 expression in skeletal muscle was elevated after voluntary exercise training with rotating wheel. Administration of recombinant human apolipoprotein C2 proteins in wild-type mice significantly suppressed plasma triglyceride, and increased apolipoprotein C2 in skeletal muscle as voluntary exercise training. These observations suggest that induction of apolipoprotein C2 may have a similar effect to exercise on lipids metabolism in skeletal muscle.
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Free Research Field |
脂質代謝
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Academic Significance and Societal Importance of the Research Achievements |
本研究は、血液中のリポ蛋白に存在し脂質代謝因子(特に、中性脂肪分解)として知られるアポリポ蛋白C2が骨格筋に存在することを初めて明らかにした。さらに運動に伴い血液中の中性脂肪が低下し、かつ骨格筋でアポリポ蛋白C2が増加することが明らかになった。アポリポ蛋白C2を野生型マウスに投与すると、血液中の中性脂肪と骨格筋アポリポ蛋白C2が運動後と同様な傾向を示した。アポリポ蛋白C2と関連する骨格筋の脂質代謝機構が未解明であるが、これらの結果から、将来的に骨格筋でこの新規脂質代謝機構を解明することで運動効果を享受できる創薬に結びつく可能性がある。
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