Elucidating the Effects of Exercise on Cognitive Function in Type 2 Diabetes Mellitus: Focus on Hippocampal Lactate Transport

2021 Fiscal Year Final Research Report

• Project/Area Number: 20K19565
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: Gunma University
• Principal Investigator: Shima Takeru 群馬大学, 共同教育学部, 講師 (60846377)
• Project Period (FY): 2020-04-01 – 2022-03-31
• Keywords: ２型糖尿病 / 海馬 / 運動 / miRNA

Outline of Final Research Achievements

The current study examined the effects of four weeks of light-intensity exercise on memory functions, hippocampal MCT2, and miRNA in type 2 diabetic animals (ob/ob mice). We found that four weeks of light-intensity exercise improved memory function and hippocampal Mct2 mRNA levels, which were reduced in sedentary ob/ob mice. Based on miR-Seq, the current exercise regimen reversed T2DM-induced alterations of hippocampal nine miRNAs. The hippocampal expression of miR-200a-3p, which is involved in the expression of Mct2, was reversed with light-intensity exercise, implying that miR-200a-3p/Mct2 in the hippocampus would be a possible clinical target for treating T2DM-induced memory dysfunction.

Free Research Field

スポーツ科学

Academic Significance and Societal Importance of the Research Achievements

本研究を通じて、２型糖尿病に伴い低下する認知機能の海馬内機構や運動効果の標的候補が見出された。薬理学的な操作を含む更なる研究を積むことで、認知機能の維持を目的とした治療標的としての有用性や、最適な運動処方を提案することにつながりうる。加えて、運動効果という生理的な生体反応を基盤として、2型糖尿病の海馬を保護する、全く新しい運動擬似薬の開発につながる可能性もある。